Drug interactions
Betaxolol + Irbesartan
Severity: Moderate
Betaxolol and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two agents lower blood pressure through different mechanisms and may cause additive hypotension or dizziness, particularly at initiation. Irbesartan can raise potassium and is fetotoxic in pregnancy.
What this interaction means in plain words
Betaxolol and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from beta-1 blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure and heart rate when starting or titrating, and check potassium and renal function periodically. Avoid irbesartan in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Betaxolol with Irbesartan?
MediHelp rates the interaction as moderate. Betaxolol and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two agents lower blood pressure through different mechanisms and may cause additive hypotension or dizziness, particularly at initiation. Irbesartan can raise potassium and is fetotoxic in pregnancy.
How serious is the interaction between Betaxolol and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating, and check potassium and renal function periodically. Avoid irbesartan in pregnancy.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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