Drug interactions
Betaxolol + Isoproterenol
Severity: Moderate
Betaxolol and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betaxolol blocks beta receptors and directly opposes the chronotropic, inotropic and bronchodilating effects of isoproterenol. The response to isoproterenol may be markedly reduced, and higher doses may be needed.
What this interaction means in plain words
Betaxolol and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Competitive beta-adrenergic receptor antagonism by betaxolol against isoproterenol agonism.
What to do
Monitor heart rate and blood pressure and titrate isoproterenol to effect, expecting higher doses to be needed. Consider an alternative strategy such as pacing in beta-blocked patients with bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Betaxolol with Isoproterenol?
MediHelp rates the interaction as moderate. Betaxolol and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Betaxolol blocks beta receptors and directly opposes the chronotropic, inotropic and bronchodilating effects of isoproterenol. The response to isoproterenol may be markedly reduced, and higher doses may be needed.
How serious is the interaction between Betaxolol and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and titrate isoproterenol to effect, expecting higher doses to be needed. Consider an alternative strategy such as pacing in beta-blocked patients with bradycardia.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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