Drug interactions
Betaxolol + Ketoprofen
Severity: Moderate
Betaxolol and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular ketoprofen use may attenuate the blood pressure lowering effect of betaxolol when it is used systemically. Ophthalmic betaxolol has limited systemic exposure, so the effect is less likely.
What this interaction means in plain words
Betaxolol and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit vasodilatory prostaglandin synthesis, causing sodium and water retention that opposes the beta-blocker.
What to do
Monitor blood pressure when ketoprofen is used for more than a few days with oral betaxolol and adjust therapy as needed. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Ketoprofen?
MediHelp rates the interaction as moderate. Betaxolol and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular ketoprofen use may attenuate the blood pressure lowering effect of betaxolol when it is used systemically. Ophthalmic betaxolol has limited systemic exposure, so the effect is less likely.
How serious is the interaction between Betaxolol and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ketoprofen is used for more than a few days with oral betaxolol and adjust therapy as needed. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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