Drug interactions
Betaxolol + Phentolamine
Severity: Moderate
Betaxolol and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine is a non-selective alpha-blocker that causes vasodilation and potentially marked hypotension. Betaxolol adds to blood pressure lowering and may blunt reflex tachycardia.
What this interaction means in plain words
Betaxolol and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade and beta-blockade.
What to do
Monitor blood pressure and heart rate when combining, especially with parenteral phentolamine. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Betaxolol with Phentolamine?
MediHelp rates the interaction as moderate. Betaxolol and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine is a non-selective alpha-blocker that causes vasodilation and potentially marked hypotension. Betaxolol adds to blood pressure lowering and may blunt reflex tachycardia.
How serious is the interaction between Betaxolol and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when combining, especially with parenteral phentolamine. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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