Drug interactions
Betaxolol + Secobarbital
Severity: Moderate
Betaxolol and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower plasma concentrations of beta-blockers metabolized by the liver. The result can be reduced beta-blocking effect, although betaxolol is partly cleared by other routes so the effect may be modest.
What this interaction means in plain words
Betaxolol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of hepatic CYP enzymes by secobarbital increases betaxolol metabolism.
What to do
Monitor heart rate and blood pressure when secobarbital is started or stopped, and increase the betaxolol dose if response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Betaxolol with Secobarbital?
MediHelp rates the interaction as moderate. Betaxolol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and may lower plasma concentrations of beta-blockers metabolized by the liver. The result can be reduced beta-blocking effect, although betaxolol is partly cleared by other routes so the effect may be modest.
How serious is the interaction between Betaxolol and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when secobarbital is started or stopped, and increase the betaxolol dose if response is reduced.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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