Drug interactions
Betaxolol + Tolfenamic acid
Severity: Moderate
Betaxolol and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular use of tolfenamic acid may reduce the antihypertensive effect of betaxolol. NSAIDs can also impair renal function and raise potassium in susceptible patients.
What this interaction means in plain words
Betaxolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis leads to sodium and water retention and opposes beta-blocker blood pressure lowering.
What to do
Monitor blood pressure if the NSAID is used for more than a few days, and use the lowest effective dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Betaxolol with Tolfenamic acid?
MediHelp rates the interaction as moderate. Betaxolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular use of tolfenamic acid may reduce the antihypertensive effect of betaxolol. NSAIDs can also impair renal function and raise potassium in susceptible patients.
How serious is the interaction between Betaxolol and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if the NSAID is used for more than a few days, and use the lowest effective dose for the shortest time.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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