Drug interactions
Bethanechol + Umeclidinium bromide
Severity: Minor
Bethanechol and Umeclidinium bromide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bethanechol is a muscarinic agonist and umeclidinium is an inhaled muscarinic antagonist, so they have opposing effects. Systemic exposure to inhaled umeclidinium is low, so the practical effect is usually limited, but bethanechol's effect could be partially blunted.
What this interaction means in plain words
Bethanechol and Umeclidinium bromide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
No dose change is usually required. Monitor for reduced response to bethanechol, such as persistent urinary retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
Frequently asked questions
Can I take Bethanechol with Umeclidinium bromide?
MediHelp rates the interaction as minor. Bethanechol and Umeclidinium bromide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bethanechol is a muscarinic agonist and umeclidinium is an inhaled muscarinic antagonist, so they have opposing effects. Systemic exposure to inhaled umeclidinium is low, so the practical effect is usually limited, but bethanechol's effect could be partially blunted.
How serious is the interaction between Bethanechol and Umeclidinium bromide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor for reduced response to bethanechol, such as persistent urinary retention.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
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