Drug interactions
Betrixaban + Fluoxetine
Severity: Moderate
Betrixaban and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs reduce platelet aggregation, and betrixaban is a factor Xa inhibitor, so the combination increases bleeding risk. Fluoxetine is not a meaningful P-gp inhibitor, so the concern is mainly pharmacodynamic.
What this interaction means in plain words
Betrixaban and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from SSRI platelet dysfunction and factor Xa inhibition.
What to do
Monitor for bleeding, including gastrointestinal bleeding, and review other bleeding-risk drugs. Consider gastroprotection if risk is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Betrixaban with Fluoxetine?
MediHelp rates the interaction as moderate. Betrixaban and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs reduce platelet aggregation, and betrixaban is a factor Xa inhibitor, so the combination increases bleeding risk. Fluoxetine is not a meaningful P-gp inhibitor, so the concern is mainly pharmacodynamic.
How serious is the interaction between Betrixaban and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, including gastrointestinal bleeding, and review other bleeding-risk drugs. Consider gastroprotection if risk is elevated.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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