Drug interactions
Betrixaban + Propafenone
Severity: Moderate
Betrixaban and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betrixaban is a P-glycoprotein substrate, and P-gp inhibition such as that from propafenone increases its exposure and bleeding risk. Labeling recommends a lower betrixaban dose with P-gp inhibitors.
What this interaction means in plain words
Betrixaban and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Propafenone inhibits P-gp efflux, increasing betrixaban absorption and reducing its clearance.
What to do
Use the reduced betrixaban regimen (80 mg once, then 40 mg daily) per labeling and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Betrixaban with Propafenone?
MediHelp rates the interaction as moderate. Betrixaban and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Betrixaban is a P-glycoprotein substrate, and P-gp inhibition such as that from propafenone increases its exposure and bleeding risk. Labeling recommends a lower betrixaban dose with P-gp inhibitors.
How serious is the interaction between Betrixaban and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced betrixaban regimen (80 mg once, then 40 mg daily) per labeling and monitor for bleeding.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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