Drug interactions
Betrixaban + Quinidine
Severity: Major
Betrixaban and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-gp, which limits betrixaban efflux and increases its absorption and exposure. Higher betrixaban levels raise the risk of bleeding.
What this interaction means in plain words
Betrixaban and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Quinidine inhibits P-gp, increasing betrixaban absorption and reducing its elimination.
What to do
Reduce the betrixaban dose as directed in labeling for P-gp inhibitors and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Betrixaban with Quinidine?
MediHelp rates the interaction as major. Betrixaban and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine inhibits P-gp, which limits betrixaban efflux and increases its absorption and exposure. Higher betrixaban levels raise the risk of bleeding.
How serious is the interaction between Betrixaban and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the betrixaban dose as directed in labeling for P-gp inhibitors and monitor for bleeding.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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