Drug interactions
Betrixaban + Verapamil
Severity: Major
Betrixaban and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein and increases betrixaban exposure, which raises bleeding risk. Labeling advises a reduced betrixaban dose with P-gp inhibitors.
What this interaction means in plain words
Betrixaban and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Verapamil inhibits P-gp-mediated efflux of betrixaban, increasing absorption and reducing clearance.
What to do
Use the reduced betrixaban dose specified in labeling for P-gp inhibitors and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Betrixaban with Verapamil?
MediHelp rates the interaction as major. Betrixaban and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Verapamil inhibits P-glycoprotein and increases betrixaban exposure, which raises bleeding risk. Labeling advises a reduced betrixaban dose with P-gp inhibitors.
How serious is the interaction between Betrixaban and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced betrixaban dose specified in labeling for P-gp inhibitors and monitor for bleeding.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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