Drug interactions
Betrixaban + Warfarin
Severity: Major
Betrixaban and Warfarin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betrixaban is a factor Xa inhibitor, so combining it with warfarin adds anticoagulant effects and increases bleeding risk. Warfarin's INR may also be altered by the DOAC.
What this interaction means in plain words
Betrixaban and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic anticoagulation by factor Xa inhibition and vitamin K antagonism.
What to do
Avoid concurrent use except during planned transition. Monitor INR and bleeding when switching between agents.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Betrixaban with Warfarin?
MediHelp rates the interaction as major. Betrixaban and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Betrixaban is a factor Xa inhibitor, so combining it with warfarin adds anticoagulant effects and increases bleeding risk. Warfarin's INR may also be altered by the DOAC.
How serious is the interaction between Betrixaban and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use except during planned transition. Monitor INR and bleeding when switching between agents.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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