Drug interactions
Bexagliflozin + Glipizide-metformin
Severity: Moderate
Bexagliflozin and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexagliflozin adds glucose-lowering effect to glipizide, which raises the risk of hypoglycemia. It also promotes volume depletion, which matters in patients on metformin.
What this interaction means in plain words
Bexagliflozin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Glipizide-metformin belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT2 inhibition and insulin secretagogue action.
What to do
Consider reducing the glipizide dose when starting bexagliflozin and monitor blood glucose and hydration status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Gliclazide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
- Bexagliflozin + Glipizide Moderate
Frequently asked questions
Can I take Bexagliflozin with Glipizide-metformin?
MediHelp rates the interaction as moderate. Bexagliflozin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexagliflozin adds glucose-lowering effect to glipizide, which raises the risk of hypoglycemia. It also promotes volume depletion, which matters in patients on metformin.
How serious is the interaction between Bexagliflozin and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glipizide dose when starting bexagliflozin and monitor blood glucose and hydration status.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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