Drug interactions
Bexagliflozin + Insulin aspart-insulin aspart protamine
Severity: Moderate
Bexagliflozin and Insulin aspart-insulin aspart protamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexagliflozin added to insulin increases the chance of hypoglycemia. Ketoacidosis risk also exists with SGLT2 inhibitors in insulin-treated patients.
What this interaction means in plain words
Bexagliflozin and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Insulin aspart-insulin aspart protamine belongs to Endocrine.
Why it happens
Additive glucose lowering via insulin-independent urinary glucose excretion.
What to do
Consider lowering the insulin dose when starting bexagliflozin and monitor glucose. Avoid abrupt large insulin reductions and check ketones if symptoms of ketoacidosis arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Glibenclamide Moderate
- Bexagliflozin + Gliclazide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
Frequently asked questions
Can I take Bexagliflozin with Insulin aspart-insulin aspart protamine?
MediHelp rates the interaction as moderate. Bexagliflozin and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexagliflozin added to insulin increases the chance of hypoglycemia. Ketoacidosis risk also exists with SGLT2 inhibitors in insulin-treated patients.
How serious is the interaction between Bexagliflozin and Insulin aspart-insulin aspart protamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting bexagliflozin and monitor glucose. Avoid abrupt large insulin reductions and check ketones if symptoms of ketoacidosis arise.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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