Drug interactions
Bexagliflozin + Lithium
Severity: Moderate
Bexagliflozin and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors may lower serum lithium concentrations, which could reduce mood stabilizer efficacy and risk relapse. Effects are reported in labeling for the class.
What this interaction means in plain words
Bexagliflozin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
Mechanism is not firmly established; increased renal lithium excretion may be involved.
What to do
Monitor serum lithium more frequently when starting bexagliflozin or changing the dose, and adjust the lithium dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Glibenclamide Moderate
- Bexagliflozin + Gliclazide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
Frequently asked questions
Can I take Bexagliflozin with Lithium?
MediHelp rates the interaction as moderate. Bexagliflozin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors may lower serum lithium concentrations, which could reduce mood stabilizer efficacy and risk relapse. Effects are reported in labeling for the class.
How serious is the interaction between Bexagliflozin and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum lithium more frequently when starting bexagliflozin or changing the dose, and adjust the lithium dose as needed.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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