Drug interactions
Bexagliflozin + Phenytoin
Severity: Moderate
Bexagliflozin and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexagliflozin is mainly cleared by UGT1A9 glucuronidation, which phenytoin may induce. Reduced bexagliflozin exposure may weaken glycemic control.
What this interaction means in plain words
Bexagliflozin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces UGT enzymes, increasing glucuronidation of bexagliflozin.
What to do
Monitor blood glucose and HbA1c. Add another antihyperglycemic agent if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Glibenclamide Moderate
- Bexagliflozin + Gliclazide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
Frequently asked questions
Can I take Bexagliflozin with Phenytoin?
MediHelp rates the interaction as moderate. Bexagliflozin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexagliflozin is mainly cleared by UGT1A9 glucuronidation, which phenytoin may induce. Reduced bexagliflozin exposure may weaken glycemic control.
How serious is the interaction between Bexagliflozin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c. Add another antihyperglycemic agent if control is inadequate.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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