Drug interactions
Bexarotene + Chlorpropamide
Severity: Moderate
Bexarotene and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene may increase the effect of insulin secretagogues and insulin sensitizers, and hypoglycemia is possible with chlorpropamide. Hypoglycemia is not reported with bexarotene alone.
What this interaction means in plain words
Bexarotene and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Chlorpropamide belongs to Endocrine.
Why it happens
Bexarotene, a retinoid X receptor agonist, may improve insulin sensitivity and so add to the sulfonylurea's glucose-lowering effect.
What to do
Monitor blood glucose when bexarotene is started and reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Chlorpropamide?
MediHelp rates the interaction as moderate. Bexarotene and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene may increase the effect of insulin secretagogues and insulin sensitizers, and hypoglycemia is possible with chlorpropamide. Hypoglycemia is not reported with bexarotene alone.
How serious is the interaction between Bexarotene and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when bexarotene is started and reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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