Drug interactions
Bexarotene + Glyburide-metformin
Severity: Moderate
Bexarotene and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene may improve insulin sensitivity and add to the effect of antidiabetic drugs, so hypoglycemia is possible, particularly with glyburide. Bexarotene can also cause hypertriglyceridemia and pancreatitis, which complicates diabetes care.
What this interaction means in plain words
Bexarotene and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Glyburide-metformin belongs to Endocrine.
Why it happens
Bexarotene's insulin-sensitizing activity is additive to the glucose-lowering effects of sulfonylureas.
What to do
Monitor blood glucose closely after starting bexarotene and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Glyburide-metformin?
MediHelp rates the interaction as moderate. Bexarotene and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene may improve insulin sensitivity and add to the effect of antidiabetic drugs, so hypoglycemia is possible, particularly with glyburide. Bexarotene can also cause hypertriglyceridemia and pancreatitis, which complicates diabetes care.
How serious is the interaction between Bexarotene and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting bexarotene and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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