Drug interactions
Bexarotene + Ifosfamide
Severity: Moderate
Bexarotene and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene may induce CYP3A4, which could increase conversion of ifosfamide to its neurotoxic and nephrotoxic chloroacetaldehyde metabolite and alter the activation of the drug. This could raise the risk of encephalopathy and kidney injury, although the clinical data are limited.
What this interaction means in plain words
Bexarotene and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Possible CYP3A4 induction by bexarotene increasing ifosfamide N-dechloroethylation and metabolite formation.
What to do
Monitor for CNS toxicity such as confusion or somnolence and for renal function changes. Consider an ifosfamide dose adjustment if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Ifosfamide?
MediHelp rates the interaction as moderate. Bexarotene and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene may induce CYP3A4, which could increase conversion of ifosfamide to its neurotoxic and nephrotoxic chloroacetaldehyde metabolite and alter the activation of the drug. This could raise the risk of encephalopathy and kidney injury, although the clinical data are limited.
How serious is the interaction between Bexarotene and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS toxicity such as confusion or somnolence and for renal function changes. Consider an ifosfamide dose adjustment if toxicity appears.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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