Drug interactions
Bexarotene + Metformin-pioglitazone
Severity: Moderate
Bexarotene and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is a retinoid X receptor agonist, and pioglitazone acts through the partner PPAR-gamma receptor, so enhanced insulin sensitization and hypoglycemia are possible. Bexarotene may also cause lipid and thyroid disturbances.
What this interaction means in plain words
Bexarotene and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Metformin-pioglitazone belongs to Endocrine.
Why it happens
RXR activation by bexarotene may add to PPAR-gamma-mediated insulin sensitization.
What to do
Monitor blood glucose when bexarotene is started and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Bexarotene and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is a retinoid X receptor agonist, and pioglitazone acts through the partner PPAR-gamma receptor, so enhanced insulin sensitization and hypoglycemia are possible. Bexarotene may also cause lipid and thyroid disturbances.
How serious is the interaction between Bexarotene and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when bexarotene is started and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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