Drug interactions
Bexarotene + Metformin-repaglinide
Severity: Moderate
Bexarotene and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is a retinoid X receptor agonist that may improve insulin sensitivity, so it could increase the glucose-lowering effect of repaglinide and metformin. Bexarotene may also induce CYP3A4, which could lower repaglinide levels.
What this interaction means in plain words
Bexarotene and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive insulin-sensitizing effect via RXR activation, with possible CYP3A4 induction affecting repaglinide.
What to do
Monitor blood glucose when starting bexarotene and adjust the repaglinide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Bexarotene and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is a retinoid X receptor agonist that may improve insulin sensitivity, so it could increase the glucose-lowering effect of repaglinide and metformin. Bexarotene may also induce CYP3A4, which could lower repaglinide levels.
How serious is the interaction between Bexarotene and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting bexarotene and adjust the repaglinide dose as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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