Drug interactions
Bexarotene + Nilotinib
Severity: Moderate
Bexarotene and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is metabolized by CYP3A4, and nilotinib may raise its levels. Bexarotene can also induce CYP3A4, which may lower nilotinib exposure, so the net effect is uncertain.
What this interaction means in plain words
Bexarotene and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by nilotinib, and possible CYP3A4 induction by bexarotene.
What to do
Monitor for bexarotene toxicity such as hypertriglyceridemia and hypothyroidism, and check nilotinib response and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Nilotinib?
MediHelp rates the interaction as moderate. Bexarotene and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is metabolized by CYP3A4, and nilotinib may raise its levels. Bexarotene can also induce CYP3A4, which may lower nilotinib exposure, so the net effect is uncertain.
How serious is the interaction between Bexarotene and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bexarotene toxicity such as hypertriglyceridemia and hypothyroidism, and check nilotinib response and ECG.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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