Drug interactions
Bictegravir + Calcium
Severity: Moderate
Bictegravir and Calcium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium-containing products can bind bictegravir in the gut and lower its absorption, risking reduced antiviral efficacy and resistance. The effect is greatest when both are taken together while fasting.
What this interaction means in plain words
Bictegravir and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Polyvalent calcium cations chelate bictegravir in the gastrointestinal tract, reducing absorption.
What to do
Bictegravir can be taken with calcium supplements together with food. Otherwise give bictegravir at least 2 hours before calcium-containing products.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Bictegravir with Calcium?
MediHelp rates the interaction as moderate. Bictegravir and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium-containing products can bind bictegravir in the gut and lower its absorption, risking reduced antiviral efficacy and resistance. The effect is greatest when both are taken together while fasting.
How serious is the interaction between Bictegravir and Calcium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Bictegravir can be taken with calcium supplements together with food. Otherwise give bictegravir at least 2 hours before calcium-containing products.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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