Drug interactions
Atazanavir + Calcium
Severity: Moderate
Atazanavir and Calcium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate antacids raise gastric pH, and atazanavir dissolves poorly at higher pH. Absorption can fall, risking subtherapeutic levels and loss of viral suppression or resistance.
What this interaction means in plain words
Atazanavir and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Calcium belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces atazanavir solubility and oral absorption.
What to do
Give atazanavir at least 2 hours before or 1 hour after calcium carbonate antacids. Monitor virologic response if calcium products are used regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
- Bictegravir + Calcium Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Calcium?
MediHelp rates the interaction as moderate. Atazanavir and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium carbonate antacids raise gastric pH, and atazanavir dissolves poorly at higher pH. Absorption can fall, risking subtherapeutic levels and loss of viral suppression or resistance.
How serious is the interaction between Atazanavir and Calcium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give atazanavir at least 2 hours before or 1 hour after calcium carbonate antacids. Monitor virologic response if calcium products are used regularly.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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