Drug interactions
Baloxavir marboxil + Calcium
Severity: Moderate
Baloxavir marboxil and Calcium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baloxavir can bind polyvalent cations such as calcium in the gut, which may lower its absorption and reduce antiviral exposure. Animal data support this, while human data are limited.
What this interaction means in plain words
Baloxavir marboxil and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baloxavir marboxil belongs to Anti Virals; Calcium belongs to Gastrointestinal Tract.
Why it happens
Chelation with polyvalent cations in the gastrointestinal tract reducing absorption.
What to do
Avoid taking baloxavir with calcium-containing supplements, antacids or dairy products. Dairy and calcium-fortified foods should also be avoided around dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Baloxavir marboxil and Calcium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
- Bictegravir + Calcium Moderate
Other interactions of Baloxavir marboxil
Frequently asked questions
Can I take Baloxavir marboxil with Calcium?
MediHelp rates the interaction as moderate. Baloxavir marboxil and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baloxavir can bind polyvalent cations such as calcium in the gut, which may lower its absorption and reduce antiviral exposure. Animal data support this, while human data are limited.
How serious is the interaction between Baloxavir marboxil and Calcium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking baloxavir with calcium-containing supplements, antacids or dairy products. Dairy and calcium-fortified foods should also be avoided around dosing.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
