Drug interactions
Bictegravir + Dapagliflozin-metformin
Severity: Moderate
Bictegravir and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bictegravir blocks renal tubular secretion of metformin, which raises metformin exposure. Higher metformin levels increase the chance of gastrointestinal intolerance and, in patients with reduced renal function, lactic acidosis.
What this interaction means in plain words
Bictegravir and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bictegravir inhibits the renal transporters OCT2 and MATE1, reducing tubular secretion and clearance of metformin.
What to do
Monitor renal function and metformin tolerability when starting or stopping bictegravir, and reduce the metformin dose if needed. Be especially careful in patients with moderate renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Bictegravir with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Bictegravir and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bictegravir blocks renal tubular secretion of metformin, which raises metformin exposure. Higher metformin levels increase the chance of gastrointestinal intolerance and, in patients with reduced renal function, lactic acidosis.
How serious is the interaction between Bictegravir and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and metformin tolerability when starting or stopping bictegravir, and reduce the metformin dose if needed. Be especially careful in patients with moderate renal impairment.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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