Drug interactions
Bictegravir + Linagliptin-metformin
Severity: Moderate
Bictegravir and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bictegravir inhibits renal tubular transporters that eliminate metformin, raising metformin concentrations. Higher exposure increases the risk of gastrointestinal effects and, rarely, lactic acidosis, especially with renal impairment.
What this interaction means in plain words
Bictegravir and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bictegravir inhibits OCT2 and MATE1, reducing renal secretion of metformin.
What to do
Monitor glycemic control and metformin tolerability, and limit the metformin dose when needed. Take extra care with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Bictegravir with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Bictegravir and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bictegravir inhibits renal tubular transporters that eliminate metformin, raising metformin concentrations. Higher exposure increases the risk of gastrointestinal effects and, rarely, lactic acidosis, especially with renal impairment.
How serious is the interaction between Bictegravir and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and metformin tolerability, and limit the metformin dose when needed. Take extra care with reduced renal function.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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