Drug interactions
Apalutamide + Linagliptin-metformin
Severity: Major
Apalutamide and Linagliptin-metformin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 and P-gp inducer and can substantially lower linagliptin levels. The glucose-lowering effect of linagliptin may be lost.
What this interaction means in plain words
Apalutamide and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Linagliptin-metformin belongs to Endocrine.
Why it happens
Strong induction of CYP3A4 and P-glycoprotein increases linagliptin elimination.
What to do
Monitor glucose closely and consider switching to a DPP-4 inhibitor or other agent not affected by induction. Adjust therapy according to glycemic response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linagliptin-metformin
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Linagliptin-metformin?
MediHelp rates the interaction as major. Apalutamide and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 and P-gp inducer and can substantially lower linagliptin levels. The glucose-lowering effect of linagliptin may be lost.
How serious is the interaction between Apalutamide and Linagliptin-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and consider switching to a DPP-4 inhibitor or other agent not affected by induction. Adjust therapy according to glycemic response.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Carbamazepine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Linagliptin-metformin page.
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