Drug interactions
Bictegravir + Saxagliptin-metformin
Severity: Moderate
Bictegravir and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bictegravir inhibits renal transporters that eliminate metformin, raising metformin plasma levels. Higher exposure increases the risk of gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Bictegravir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bictegravir inhibits OCT2 and MATE1, reducing renal tubular secretion of metformin.
What to do
Monitor renal function and metformin tolerability, and reduce the metformin dose if adverse effects or risk factors for lactic acidosis appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Bictegravir with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Bictegravir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bictegravir inhibits renal transporters that eliminate metformin, raising metformin plasma levels. Higher exposure increases the risk of gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Bictegravir and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and metformin tolerability, and reduce the metformin dose if adverse effects or risk factors for lactic acidosis appear.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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