Drug interactions
Bimekizumab + Cyclosporin
Severity: Moderate
Bimekizumab and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blocking IL-17 can reverse cytokine-mediated suppression of CYP enzymes, potentially lowering the concentrations of CYP3A substrates. For cyclosporin, concentrations may shift and affect immunosuppression or toxicity.
What this interaction means in plain words
Bimekizumab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bimekizumab belongs to Miscellaneous; Cyclosporin belongs to Miscellaneous.
Why it happens
Normalization of cytokine-suppressed CYP450 (CYP3A4) expression may change cyclosporin clearance.
What to do
Measure cyclosporin trough concentrations and renal function after starting or stopping bimekizumab. Adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bimekizumab
- Bimekizumab + Warfarin Moderate
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Bimekizumab with Cyclosporin?
MediHelp rates the interaction as moderate. Bimekizumab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blocking IL-17 can reverse cytokine-mediated suppression of CYP enzymes, potentially lowering the concentrations of CYP3A substrates. For cyclosporin, concentrations may shift and affect immunosuppression or toxicity.
How serious is the interaction between Bimekizumab and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure cyclosporin trough concentrations and renal function after starting or stopping bimekizumab. Adjust the dose as needed.
What other medicines interact with Bimekizumab?
MediHelp also lists interactions of Bimekizumab with, for example, Warfarin. The full list is on the Bimekizumab page.
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