Drug interactions
Bimekizumab + Warfarin
Severity: Moderate
Bimekizumab and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhibition of IL-17 can reverse cytokine-mediated suppression of CYP enzymes, potentially altering the metabolism of narrow therapeutic index drugs. For warfarin this may change the INR when bimekizumab is started or stopped.
What this interaction means in plain words
Bimekizumab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bimekizumab belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
Normalization of cytokine-suppressed CYP450 expression may change warfarin clearance.
What to do
Check INR more frequently after starting or stopping bimekizumab. Adjust the warfarin dose according to INR.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bimekizumab
- Bimekizumab + Cyclosporin Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Bimekizumab with Warfarin?
MediHelp rates the interaction as moderate. Bimekizumab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhibition of IL-17 can reverse cytokine-mediated suppression of CYP enzymes, potentially altering the metabolism of narrow therapeutic index drugs. For warfarin this may change the INR when bimekizumab is started or stopped.
How serious is the interaction between Bimekizumab and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more frequently after starting or stopping bimekizumab. Adjust the warfarin dose according to INR.
What other medicines interact with Bimekizumab?
MediHelp also lists interactions of Bimekizumab with, for example, Cyclosporin. The full list is on the Bimekizumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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