Drug interactions
Bisoprolol + Celecoxib
Severity: Moderate
Bisoprolol and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may reduce the antihypertensive effect of bisoprolol, particularly with sustained use.
What this interaction means in plain words
Bisoprolol and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
Prostaglandin inhibition causes sodium and water retention and blunts vasodilation, opposing beta-blocker effect.
What to do
Monitor blood pressure and adjust antihypertensive therapy as needed when celecoxib is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Celecoxib?
MediHelp rates the interaction as moderate. Bisoprolol and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib may reduce the antihypertensive effect of bisoprolol, particularly with sustained use.
How serious is the interaction between Bisoprolol and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust antihypertensive therapy as needed when celecoxib is started or stopped.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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