Drug interactions
Bisoprolol + Diflunisal
Severity: Moderate
Bisoprolol and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal can reduce the blood pressure lowering effect of bisoprolol when used for more than a short course.
What this interaction means in plain words
Bisoprolol and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and water retention, opposing the beta-blocker.
What to do
Monitor blood pressure during prolonged diflunisal use and adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Diflunisal?
MediHelp rates the interaction as moderate. Bisoprolol and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal can reduce the blood pressure lowering effect of bisoprolol when used for more than a short course.
How serious is the interaction between Bisoprolol and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during prolonged diflunisal use and adjust antihypertensive therapy if control worsens.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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