Drug interactions
Bisoprolol + Etodolac
Severity: Moderate
Bisoprolol and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can weaken the antihypertensive effect of bisoprolol, especially when taken regularly for more than a short time. This may result in higher blood pressure than expected.
What this interaction means in plain words
Bisoprolol and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
NSAID-induced prostaglandin inhibition causes sodium and water retention and reduced vasodilation, opposing beta-blocker blood pressure lowering.
What to do
Check blood pressure after starting or stopping etodolac and titrate antihypertensives accordingly. Limit NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Etodolac?
MediHelp rates the interaction as moderate. Bisoprolol and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac can weaken the antihypertensive effect of bisoprolol, especially when taken regularly for more than a short time. This may result in higher blood pressure than expected.
How serious is the interaction between Bisoprolol and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure after starting or stopping etodolac and titrate antihypertensives accordingly. Limit NSAID dose and duration.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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