Drug interactions
Bisoprolol + Fosinopril-hydrochlorothiazide
Severity: Moderate
Bisoprolol and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol with an ACE inhibitor and thiazide gives additive blood pressure reduction and is a common regimen. Hypotension and bradycardia may occur, and thiazides can alter potassium and glucose.
What this interaction means in plain words
Bisoprolol and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects via beta-blockade, ACE inhibition and diuresis.
What to do
Monitor blood pressure, heart rate and serum potassium during initiation and dose changes. Adjust doses if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bisoprolol and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol with an ACE inhibitor and thiazide gives additive blood pressure reduction and is a common regimen. Hypotension and bradycardia may occur, and thiazides can alter potassium and glucose.
How serious is the interaction between Bisoprolol and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium during initiation and dose changes. Adjust doses if hypotension or bradycardia occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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