Drug interactions
Bisoprolol + Ketoprofen
Severity: Moderate
Bisoprolol and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular ketoprofen use can reduce the antihypertensive effect of bisoprolol. The effect is most relevant with continued NSAID use.
What this interaction means in plain words
Bisoprolol and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit vasodilatory prostaglandin synthesis, causing sodium and water retention that opposes the beta-blocker.
What to do
Monitor blood pressure when ketoprofen is used regularly with bisoprolol and adjust antihypertensive therapy if needed. Use the shortest possible NSAID course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Ketoprofen?
MediHelp rates the interaction as moderate. Bisoprolol and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular ketoprofen use can reduce the antihypertensive effect of bisoprolol. The effect is most relevant with continued NSAID use.
How serious is the interaction between Bisoprolol and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ketoprofen is used regularly with bisoprolol and adjust antihypertensive therapy if needed. Use the shortest possible NSAID course.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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