Drug interactions
Bisoprolol + Levodopa
Severity: Moderate
Bisoprolol and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, especially at initiation. When combined with bisoprolol, blood pressure lowering may be enhanced and cause dizziness or falls.
What this interaction means in plain words
Bisoprolol and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotension from levodopa-derived dopamine vasodilation and beta-blockade.
What to do
Measure sitting and standing blood pressure when levodopa is started or increased. Reduce the bisoprolol dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Bisoprolol with Levodopa?
MediHelp rates the interaction as moderate. Bisoprolol and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, especially at initiation. When combined with bisoprolol, blood pressure lowering may be enhanced and cause dizziness or falls.
How serious is the interaction between Bisoprolol and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure sitting and standing blood pressure when levodopa is started or increased. Reduce the bisoprolol dose if symptomatic hypotension develops.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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