Drug interactions
Bisoprolol + Nadolol
Severity: Major
Bisoprolol and Nadolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta1-selective blocker with a nonselective one is duplication that increases bradycardia, hypotension and AV block risk. The nonselective agent also adds bronchospasm risk in susceptible patients.
What this interaction means in plain words
Bisoprolol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bisoprolol belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic receptor blockade.
What to do
Avoid using two beta-blockers together; choose a single agent. If overlap occurs, stop one and monitor heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bisoprolol
Other interactions of Nadolol
Frequently asked questions
Can I take Bisoprolol with Nadolol?
MediHelp rates the interaction as major. Bisoprolol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a beta1-selective blocker with a nonselective one is duplication that increases bradycardia, hypotension and AV block risk. The nonselective agent also adds bronchospasm risk in susceptible patients.
How serious is the interaction between Bisoprolol and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two beta-blockers together; choose a single agent. If overlap occurs, stop one and monitor heart rate and blood pressure.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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