Drug interactions
Amiodarone + Nadolol
Severity: Major
Amiodarone and Nadolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow the sinus rate and AV conduction, so combined use may cause symptomatic bradycardia, AV block or hypotension. The risk is highest in older patients or those with conduction disease or heart failure.
What this interaction means in plain words
Amiodarone and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects through beta blockade and amiodarone's channel and adrenergic effects.
What to do
Monitor heart rate, blood pressure and ECG, especially after initiation or dose increases. Reduce the nadolol dose or stop one drug if significant bradycardia or block develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Arformoterol + Nadolol Major
- Atenolol-chlorthalidone + Nadolol Major
Frequently asked questions
Can I take Amiodarone with Nadolol?
MediHelp rates the interaction as major. Amiodarone and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow the sinus rate and AV conduction, so combined use may cause symptomatic bradycardia, AV block or hypotension. The risk is highest in older patients or those with conduction disease or heart failure.
How serious is the interaction between Amiodarone and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially after initiation or dose increases. Reduce the nadolol dose or stop one drug if significant bradycardia or block develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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