Drug interactions
Bisoprolol + Nicardipine
Severity: Moderate
Bisoprolol and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, and the combination can cause additive hypotension. Beta-blockade may blunt reflex tachycardia from nicardipine, and rarely heart failure can worsen in vulnerable patients.
What this interaction means in plain words
Bisoprolol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from beta-blockade and dihydropyridine calcium channel vasodilation, with possible additive negative inotropy.
What to do
Monitor blood pressure and heart rate when starting or changing doses, with particular care in patients with left ventricular dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Nicardipine
Frequently asked questions
Can I take Bisoprolol with Nicardipine?
MediHelp rates the interaction as moderate. Bisoprolol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, and the combination can cause additive hypotension. Beta-blockade may blunt reflex tachycardia from nicardipine, and rarely heart failure can worsen in vulnerable patients.
How serious is the interaction between Bisoprolol and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or changing doses, with particular care in patients with left ventricular dysfunction.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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