Drug interactions
Bisoprolol + Nimodipine
Severity: Moderate
Bisoprolol and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nimodipine and bisoprolol both reduce blood pressure, so together they may cause marked hypotension. This matters especially in subarachnoid hemorrhage patients, where cerebral perfusion pressure must be maintained. Negative inotropic effects may also add up in patients with impaired cardiac function.
What this interaction means in plain words
Bisoprolol and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Nimodipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from calcium channel blockade and beta-adrenergic blockade.
What to do
Monitor blood pressure and heart rate closely, particularly during nimodipine initiation. Hold or reduce the dose of the antihypertensive if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Bisoprolol with Nimodipine?
MediHelp rates the interaction as moderate. Bisoprolol and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nimodipine and bisoprolol both reduce blood pressure, so together they may cause marked hypotension. This matters especially in subarachnoid hemorrhage patients, where cerebral perfusion pressure must be maintained. Negative inotropic effects may also add up in patients with impaired cardiac function.
How serious is the interaction between Bisoprolol and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely, particularly during nimodipine initiation. Hold or reduce the dose of the antihypertensive if hypotension develops.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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