Drug interactions
Bisoprolol + Secobarbital
Severity: Minor
Bisoprolol and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower plasma concentrations of beta-blockers metabolized by the liver. For bisoprolol, which is cleared about equally by liver and kidney, the effect is likely modest, but reduced heart rate and blood pressure control are possible.
What this interaction means in plain words
Bisoprolol and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bisoprolol belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of hepatic CYP enzymes (notably CYP3A4) by secobarbital increases bisoprolol metabolism.
What to do
Monitor heart rate and blood pressure when starting or stopping secobarbital, and adjust the bisoprolol dose if response diminishes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bisoprolol
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Bisoprolol with Secobarbital?
MediHelp rates the interaction as minor. Bisoprolol and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and may lower plasma concentrations of beta-blockers metabolized by the liver. For bisoprolol, which is cleared about equally by liver and kidney, the effect is likely modest, but reduced heart rate and blood pressure control are possible.
How serious is the interaction between Bisoprolol and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping secobarbital, and adjust the bisoprolol dose if response diminishes.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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