Drug interactions
Bisoprolol + Sulindac
Severity: Moderate
Bisoprolol and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac can weaken the antihypertensive effect of bisoprolol, especially when taken regularly for more than a week. Blood pressure may rise and heart failure patients may retain fluid.
What this interaction means in plain words
Bisoprolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID-mediated inhibition of prostaglandin synthesis causes sodium and fluid retention and vasoconstriction, opposing beta-blocker effects.
What to do
Check blood pressure regularly during co-therapy and adjust the antihypertensive regimen if needed. Prefer the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bisoprolol and Sulindac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Sulindac?
MediHelp rates the interaction as moderate. Bisoprolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac can weaken the antihypertensive effect of bisoprolol, especially when taken regularly for more than a week. Blood pressure may rise and heart failure patients may retain fluid.
How serious is the interaction between Bisoprolol and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure regularly during co-therapy and adjust the antihypertensive regimen if needed. Prefer the lowest NSAID dose for the shortest time.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
