Drug interactions
Bitter melon + Captopril-hydrochlorothiazide
Severity: Minor
Bitter melon and Captopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bitter melon may lower blood glucose and has been linked to potassium shifts, which could add to the potassium loss from hydrochlorothiazide. Clinical evidence is sparse.
What this interaction means in plain words
Bitter melon and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive effects on potassium and glucose; mechanism not firmly established.
What to do
Monitor serum potassium and glucose if bitter melon is used regularly, particularly in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Bitter melon with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Bitter melon and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bitter melon may lower blood glucose and has been linked to potassium shifts, which could add to the potassium loss from hydrochlorothiazide. Clinical evidence is sparse.
How serious is the interaction between Bitter melon and Captopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and glucose if bitter melon is used regularly, particularly in diabetic patients.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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