Drug interactions
Bitter melon + Dapagliflozin-metformin
Severity: Moderate
Bitter melon and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bitter melon has glucose-lowering activity and may add to the effect of antidiabetic drugs. Hypoglycemia is possible, though it is more likely with insulin or insulin secretagogues.
What this interaction means in plain words
Bitter melon and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bitter melon constituents increase glucose uptake and have insulin-like effects, adding to glucose lowering.
What to do
Advise patients to monitor blood glucose closely if using bitter melon and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Bitter melon with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Bitter melon and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bitter melon has glucose-lowering activity and may add to the effect of antidiabetic drugs. Hypoglycemia is possible, though it is more likely with insulin or insulin secretagogues.
How serious is the interaction between Bitter melon and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor blood glucose closely if using bitter melon and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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