Drug interactions
Bitter melon + Fosinopril-hydrochlorothiazide
Severity: Minor
Bitter melon and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bitter melon has been reported to have hypoglycemic activity and possibly mild potassium-lowering effects. Combined with a thiazide, theoretical additive hypokalemia could occur, though clinical data are scarce.
What this interaction means in plain words
Bitter melon and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive potassium loss; mechanism of the herb's effect is not well established.
What to do
Monitor serum potassium if bitter melon is used regularly alongside the thiazide. Advise patients to report weakness or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Bitter melon with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Bitter melon and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bitter melon has been reported to have hypoglycemic activity and possibly mild potassium-lowering effects. Combined with a thiazide, theoretical additive hypokalemia could occur, though clinical data are scarce.
How serious is the interaction between Bitter melon and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium if bitter melon is used regularly alongside the thiazide. Advise patients to report weakness or palpitations.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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