Drug interactions
Bitter melon + Hydrochlorothiazide-losartan
Severity: Minor
Bitter melon and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bitter melon has glucose-lowering and possibly potassium-lowering effects reported in limited data. Combined with a thiazide, additive hypokalemia is theoretically possible, although clinical evidence is sparse.
What this interaction means in plain words
Bitter melon and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive potassium loss; the mechanism is not well established.
What to do
Monitor serum potassium if bitter melon is used regularly. Ask patients with diabetes to watch blood glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Bitter melon with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Bitter melon and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bitter melon has glucose-lowering and possibly potassium-lowering effects reported in limited data. Combined with a thiazide, additive hypokalemia is theoretically possible, although clinical evidence is sparse.
How serious is the interaction between Bitter melon and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium if bitter melon is used regularly. Ask patients with diabetes to watch blood glucose.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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