Drug interactions
Bitter melon + Tolazamide
Severity: Moderate
Bitter melon and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bitter melon has glucose-lowering activity and may add to the effect of sulfonylureas, increasing the chance of hypoglycemia. Product potency varies widely.
What this interaction means in plain words
Bitter melon and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering through insulin-like and insulin-sensitizing constituents.
What to do
Monitor blood glucose if the patient uses bitter melon, and advise telling the clinician about supplement use. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Bitter melon with Tolazamide?
MediHelp rates the interaction as moderate. Bitter melon and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bitter melon has glucose-lowering activity and may add to the effect of sulfonylureas, increasing the chance of hypoglycemia. Product potency varies widely.
How serious is the interaction between Bitter melon and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if the patient uses bitter melon, and advise telling the clinician about supplement use. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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