Drug interactions
Bivalirudin + Celecoxib
Severity: Moderate
Bivalirudin and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor, and celecoxib can cause gastrointestinal bleeding and has some effect on platelets. The combination may increase bleeding risk, though bivalirudin is short-acting and used mostly in procedures.
What this interaction means in plain words
Bivalirudin and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from direct thrombin inhibition and NSAID effects on mucosa and platelets.
What to do
Monitor for bleeding during and after bivalirudin infusion, and avoid starting NSAIDs peri-procedurally unless necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Bivalirudin with Celecoxib?
MediHelp rates the interaction as moderate. Bivalirudin and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor, and celecoxib can cause gastrointestinal bleeding and has some effect on platelets. The combination may increase bleeding risk, though bivalirudin is short-acting and used mostly in procedures.
How serious is the interaction between Bivalirudin and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding during and after bivalirudin infusion, and avoid starting NSAIDs peri-procedurally unless necessary.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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