Drug interactions
Bivalirudin + Cilostazol
Severity: Moderate
Bivalirudin and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor and cilostazol inhibits platelet aggregation, so together they increase bleeding risk. This is routine in some procedural settings but needs attention to bleeding.
What this interaction means in plain words
Bivalirudin and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects of direct thrombin inhibition and PDE3-mediated platelet inhibition.
What to do
Monitor for bleeding and clotting time (ACT) during bivalirudin use. Consider holding cilostazol around procedures in patients at high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Bivalirudin with Cilostazol?
MediHelp rates the interaction as moderate. Bivalirudin and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor and cilostazol inhibits platelet aggregation, so together they increase bleeding risk. This is routine in some procedural settings but needs attention to bleeding.
How serious is the interaction between Bivalirudin and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and clotting time (ACT) during bivalirudin use. Consider holding cilostazol around procedures in patients at high bleeding risk.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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